Abstract
Intratumoral APCs such as dendritic cells (DCs) and tumor-associated macrophages (TAMs) play a key role in initiation of anti-tumor antigen specific immunity especially when polarized to mature CD80 positive (DCs) vs immature phenotypes and pro-inflammatory phenotypes (M1) vs tissue healing phenotypes (M2). Thermal tumor ablation (with RFA) can induce increased and altered intratumoral immune cell trafficking. However, variable thermal doses have been shown to induce different intratumoral cellular infiltration patterns.
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