Abstract
Direct injection of the TLR-9 agonist SD-101 oligonucleotide has shown promising results for the treatment of superficial cutaneous melanoma metastatic lesions in combination with checkpoint inhibition. However, this mode of delivery is limited to easily discernable tumors located in superficial locations. Here we compare local infusion of labeled SD-101 into hepatic tissue using the Pressure Enabled Drug Delivery (PEDD) method vs. direct needle injection. PEDD has been shown to increase the concentration and penetration of therapeutics into tumors, while limiting exposure to off-target tissue.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
