Abstract
Lipiodol is the only clinically available liquid embolic used in locoregional therapy for liver cancer. Phase-inverting agents such as Onyx are embolic systems consisting of water-insoluble polymers dissolved in water-miscible solvents which exert their therapeutic effects by precipitating into a solid state upon interacting with aqueous compounds such as blood. This study seeks to characterize the embolic effects and depth of vascular occlusion of a novel biodegradable radiopaque in situ forming implant (BRISFI) in an in-vivo liver cancer model in rats by modulating its phase-inverting properties via alterations in the polymer to solvent ratio.
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