Abstract
Ultrasound (US)-mediated gene delivery (UMGD) with microbubbles (MBs) is a promising strategy for transvascular gene therapy. Systemically administered cationic MBs (+MBs), engineered to directly bind, transport, and protect anionic DNA, may increase plasmid DNA at the site of sonoporation. To test whether +MBs potentiate UMGD, efficiency of UMGD using +MBs versus control neutral MBs (ntMBs) were compared in cell culture and mouse tumor models.
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