Abstract
Abstract Breast cancer metastasis develops from disseminated cancer cells (DCCs) that leave the primary tumor and seed in distant organs. In those organs, DCCs undergo a period of dormancy during which cancer cells remain occult, in a non-proliferative state, before metastases become detectable. In this seminar I will discuss how disseminated cancer cells enter in dormancy at metastatic sites and the importance of the ECM in this process. We have found that dormant cancer cells express a specific set of ECM genes, "the matrisome", that is lost upon break from dormancy. ECM proteomics identify tumor-derived COL3A1 as a key ECM component required for tumor cell dormancy at metastatic organs. Intravital imaging and SHG microscopy reveals that the dormancy-to-reactivation transition is accompanied by changes in collagen three-dimensional architecture. Our data reveal a novel barrier to metastasis through a mechanism by which DCCs depend on the assembly of a pro-quiescence ECM to establish a niche that sustains dormancy. Citation Format: Jose Javier Bravo-Cordero. Extra cellular matrix and dormancy [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr MS2-2.
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