Abstract MP66: Accelerometer Measured Diurnal Movement Patterns Associated With Frailty in Older Adults: UK Biobank

Abstract

Introduction: Frailty is a significant health challenge for the aging population. Older adults with cardiovascular diseases (CVD) tend to be physically inactive and have a high risk of frailty. Little is known about the relationship between diurnal movement patterns and frailty and whether this association differs in older adults with and without CVD. Hypothesis: Less morning, afternoon, and evening movements but more night movements are associated with frailty, especially among those with CVD. Methods: This cross-sectional study included 10,082 participants ≥ 65 years (66.8±1.5 years; 49% female) from UK Biobank. CVD status was identified using ICD-9&10 diagnosis and self-reported CVD. Participants wore Axivity AX3 on the dominant wrist for 7 days, 24 hours/day. Mean accelerations during night (12-6 am), morning (6 am-12 pm), afternoon (12-6 pm) and evening (6 pm-12 am) were calculated. Frailty was determined using Modified Fried Frailty Phenotype. Multivariate logistic regression models were used to examine associations between total movement and diurnal movement patterns with frailty, stratified by CVD status. Results: The diurnal movement patterns showed lower movements during night, increasing during morning, peaking at noon, and decreasing in afternoon and evening, with frail CVD adults having the lowest accelerations during all daytime hours (6 am-midnight). In both CVD and non-CVD older adults, each 5 mg higher overall mean acceleration was associated with 11-18% lower odds of frailty ( Table ). Each 5 mg higher mean acceleration during morning, afternoon and evening was associated with 5-10% lower odds of frailty ( Table ). Every 5 mg higher mean acceleration during night was associated with 14% higher odds of frailty only in non-CVD older adults ( Table ). Conclusions: More activity during any daytime period was associated with lower odds of frailty among older adults in both with and without CVD. Greater night activity was associated with higher odds of frailty, primarily observed in older adults without CVD.