Abstract MP65: Multimorbidity Trajectories From Early Adulthood and Current and Subsequent Accelerometer-Measured Sedentary and Physical Activity Behaviors in Midlife: Coronary Artery Risk Development in Young Adults (CARDIA) Study

Abstract

Introduction: Multimorbidity, having two or more chronic diseases, can lead to functional limitations. However limited data exist on the associations of multimorbidity during the early life-course with physical activity (PA). We assessed the hypothesis that patterns of multimorbidity accumulation from early to mid- adulthood is associated with differences in 1) concurrent PA and 2) changes in PA during midlife. Methods: We analyzed subsamples of CARDIA participants who wore an accelerometer (ActiGraph GT3X) on the waist ≥4 days with ≥10 hr/day during the Year 30 (2015-16; n = 1425) and again at Year 35 (2020-22; n = 745 of 1425) follow-up exams. Accelerometer estimates included time (min/day) spent in sedentary (SB), light intensity (LPA), or moderate to vigorous intensity PA (MVPA) behaviors. Six identified latent trajectories of early- to mid- life multimorbidity based on age and rate of accumulation included: 1) mid-20s fast; 2) mid-20s slow; 3) late-20s fast; 4) mid-30s fast; 5) mid-40s fast; and 6) early-50s slow [referent]. Linear models were used to estimate differences in 1) behaviors at Year 30 and 2) relative change (%) from Year 30 to Year 35 by multimorbidity trajectory, after adjustment. Results: CARDIA adults (overall: 62% female, 45% Black, mean age = 55 at Year 30) in the early-50s slow group had the highest MVPA (54.5 min/day) and LPA (348 min/day) and least SB (515 min/day) (unadjusted χ 2 : p < 0.01). At Year 30, when compared to early-50s slow, mid-20s slow had lower LPA (β = -17.1, p = 0.003) and late-20s fast had lower MVPA (β = -12.0, p < 0.001) after covariate adjustment. No significant differences in 5-year relative change in any activity were found by multimorbidity trajectory (Figure). Conclusions: In this prospective cohort, adults who accumulated disease later (early-50s) had higher PA at midlife. Changes in midlife PA and SB did not differ by multimorbidity trajectory, however this was a relatively short follow-up. Additional follow-up will provide clarity as CARDIA participants transition into older adulthood.