Abstract MP59: Association Between Time-varying Sleep Quality Status And Hypertriglyceridemia Onset In Middle-aged Population

Abstract

Introduction: Deteriorated sleep quality adversely affects insulin sensitivity and inflammation markers, and these factors are commonly associated with triglyceride levels. However, the long-term effects of sleep quality on fasting triglyceride levels have not been investigated in previous studies. Hypothesis: We assessed the hypothesis that whether time-varying sleep quality affects the risk of hypertriglyceridemia among healthy middle-aged Koreans. Methods: Participants in the Korean Genome and Epidemiology Study were biennially followed up from the baseline. Sleep quality was assessed five times measured over 14 years by the Pittsburgh Sleep Quality Index (PSQI). We utilized data on 1,773 participants (mean age: 49.8) with at least three measures of sleep quality data and without dyslipidemia at baseline. Poor sleep was determined as PSQI >7. Blood samples were collected from every survey and the first visit of triglyceride≥200 mg/dL was defined as hypertriglyceridemia. Cox proportional hazard models with time-varying sleep quality were employed to estimate the effects of time-varying sleep quality on the risk of hypertriglyceridemia. Adjusted covariates included age, socioeconomic factors, body mass index, baseline blood lipids, insulin sensitivity, menopausal status, psychological stress, comorbidities, frequency of night-snack, smoking, drinking, and physical activity. All analyses were conducted separately in men and women. Results: During a median follow-up of 11.8 years, 233 men (28.2%) and 192 women (20.1%) developed hypertriglyceridemia. Sleep quality as a time-varying element was significantly associated with the risk of developing hypertriglyceridemia in women after full adjustments; poor sleep increased 53% of hazards for developing hypertriglyceridemia in women (hazard ratio 1.53; 95% confidence interval 1.07-2.17), but not in men (hazard ratio 1.03; 95% confidence interval 0.68-1.55). A sensitivity analysis, which was adjusted for a time-varying status of alcohol drinking and physical activity, showed similar findings. Another sensitivity results with the complete case of sleep quality data were similar to the main results. Conclusions: In conclusion, maintaining good sleep quality may have cardiovascular prevention effects, through preventing hypertriglyceridemia, in middle-aged women.