Abstract MP21: Mobile Interventional Stroke Teams Lead to Improved Outcomes in the Early Time Window for LVO Stroke

Abstract

Introduction: Endovascular therapy (EVT) for large vessel occlusion (LVO) stroke is time-sensitive. At Mount Sinai Health System, we developed a novel Mobile Interventional Stroke Team (MIST) that travels to Thrombectomy Capable Stroke Centers to perform EVT, as opposed to transferring patients in the Drip-and-Ship (DS) model. We have shown significantly faster initial door-to-recanalization times and improved discharge outcomes. The effect of the MIST stratified by time of presentation has yet to be studied. Hypothesis: In patients presenting with a last known well [LKW] of <6 hours, the MIST model leads to better clinical outcomes as compared to the DS model. Methods: In a prospectively collected stroke database at a multicenter health system, patients undergoing EVT performed by a MIST or after transfer in a DS model from January 2017 to March 2020 with baseline mRS 0-2 were selected. Patients presenting in the early time window and late time window (LKW >6 hours) were analyzed separately. The primary endpoint was the proportion with a good outcome (mRS of 0-2) at 90 days. Secondary endpoints included discharge NIHSS and mRS. Results: In the 242 selected patients, the MIST and DS cohorts were similar in age, gender, initial NIHSS, pre-stroke mRS, and procedural details. In the early window, 54% (39/72) had a good 90-day outcome in the MIST model, as compared to 28% (25/88) in the DS model (p<0.01). In the late window, good 90-day outcomes were similar (29% vs 43%; p=0.40). The median NIHSS at discharge was 4.0 and 12.0 in the early window (p<0.01) and 5.0 and 11.0 in the late window (p=0.16) in the MIST and DS models, respectively. The early window discharge mRS was significantly better in the MIST model (p<0.01) and similar in the late window (p=0.74). Conclusions: The MIST model used in the early time window produces better 90-day outcomes compared to the DS model. This is likely due to the MIST’s ability to capture fast progressors in the early window.