Abstract MP05: Life’s Simple 7 and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis

Abstract

Background: The concept of Life’s Simple 7 (LS7) metrics was introduced by the American Heart Association to assess and promote cardiovascular health. Individuals with favorable LS7 scores have a lower incidence of cardiovascular disease. In this study, we examined the association between the LS7 metrics and incident heart failure (HF) Methods: We analyzed data from the Multi-Ethnic Study of Atherosclerosis, a multicenter cohort study that included 6,814 participants free of established cardiovascular disease, between the ages of 45 and 84. The components of the LS7 metrics (smoking, physical activity, body mass index, diet, blood pressure, total cholesterol and blood glucose) were graded on a scale of 0-2, with 2 indicating “ideal” status, 1 indicating “intermediate” status and 0 indicating “poor” status. These scores were summed for each participant, thus, the LS7 score created ranged from 0 to 14. Hazard ratios and incidence rates of HF per 1000 person-years were calculated Results: After exclusion of participants with incomplete data, the final study population was 6,506 (53% female mean age 62 ±10 years). In a median follow up of 10.2 years, 181 (2.8%) participants developed HF. The incidence of HF decreased as the number of ideal LS7 metrics increased 6.5 per 1000 person-years for participants with 0-1 ideal metrics compared to 1.3 per 1000 person-years for those with 5 ideal metrics (Table). No HF event was reported in participants with 6-7 ideal metrics at baseline. In comparison to participants with 0-1 ideal metrics, having 2, 3, 4, and 5 ideal metrics was associated with an 11%, 36%, 59% and 76% lower hazard for HF respectively. In addition, optimal and average LS7 scores were associated with an 80% and 51% lower hazard for HF, respectively Conclusion: The American Heart Association LS7 metrics was associated with a lower incidence of HF in a follow up extending up to 10 years. These findings suggest that efforts to achieve ideal cardiovascular health metrics favorably reduce the risk of HF, a major source of morbidity and mortality