Abstract
Abstract Genome-Wide Association Studies (GWAS) and whole-genome resequencing studies identified thousands of germline risk variants and somatic mutations in cancer. However, efforts to interpret these data have mainly focused on protein coding genes, despite the fact that majority of these genetic alterations locate outside of coding gene exons. A recent curation of over seven thousand RNA-seq data characterized more than fifty-eight thousand expressed long noncoding RNAs (lncRNAs) in human genome, twice as large as the number of protein coding genes. In this study, we integrated lncRNA gene expression, epigenetic and genetic alteration data to nominate potential driver lncRNAs in prostate cancer. We have identified eleven lncRNAs that are regulated by risk SNPs and somatic mutations through both cis and trans actions. The function of two of these lncRNAs in prostate cancer development and progression has been characterized. Our data suggests that lncRNAs may function as driving factors in prostate cancer development and progression. Note: This abstract was not presented at the meeting. Citation Format: Haiyang Guo, Musaddeque Ahmed, Junjie Hua, Yi Liang, Jens Langstein, Housheng Hansen He. Integrative analysis identifies driver lncRNAs in prostate cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-297. doi:10.1158/1538-7445.AM2015-LB-297
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