Abstract LB073: NCI’s broad-use collections: Accelerating discovery process by improving access to individual-level genomics and other -omics data

Abstract

Abstract Genomic data sharing increases our understanding of factors that influence health and diseases by enabling additional research questions from secondary data users, increasing statistical power through combining multiple data sources, facilitating reproducibility and validation of research results, and supporting innovation with the development of research tools and methodologies. Research using large-scale genomic and other-omics data is no longer limited by storage space or slow downloading speed for individual datasets. Innovations like cloud infrastructure enable computing over many datasets at multiple locations at once. These developments have increased the need for faster, more efficient processes for data access and sharing. To support scientific exploration and meet the demand for analysis of biomedical data, the National Cancer Institute (NCI) has created two large collections of the broad-use studies within the database of Genotypes and Phenotypes (dbGaP). These collections comply with the consent of the study (data use limitations) for how secondary access to studies are determined. NCI’s Collection of Datasets for General Research Use comprises 284 studies with individual-level data sets, and permits approved users to explore broad research interest, including methods and tool development. NCI’s Collection of Datasets for Health, Medical, and Biomedical (HMB) Research Purposes is comprised of 65 studies of individual-level that are permitted for research interests specific to any health, medical, or biomedical research only. The HMB collection could be used for methods and tool development; research interests involving ancestry/populations studies must be dependent on a health/medical condition. Through these collections, investigators will have the potential to add access to 349 datasets to their approved research projects or submit a new project request for access to the broad-use collections. As new genomic studies are registered by NCI for release through dbGaP, they will be automatically added to these collections. NCI anticipates through the implementation of these broad-use collections a requestor could have access to approximately 70% of NCI’s studies in controlled-access repositories.The streamlined access to broad-use datasets expedites data sharing and potentially accelerates the discovery process. This approach reduces redundancies for obtaining controlled-access data. Citation Format: Freddie L. Pruitt, Michael Feolo, Subhashini Jagu, Jaime Guidry Auvil. NCI’s broad-use collections: Accelerating discovery process by improving access to individual-level genomics and other -omics data [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB073.