Abstract LB-391: The modified effect of obesity on the association between height and cancer incidence

Abstract

Abstract Height has been regarded as anthropometric marker of early-life environments and reported the association with the risk of cancer incidence and mortality although the results were not consistent for some site-specific cancers. This study was aimed to evaluate the association between height and cancer incidence among Korean and the modification effects at BMI on the association. In addition, the association between height and the mortality of 5 major cancer sites was analyzed. The study participants of 1,067,923 Koreans (609,560 men and 458,363 women) aged 30-65 years was included in the follow-up or cancer incidence and mortality between 1993 and 2005. Study participants were divided into quartile according to their height. The lower quartile served as the reference group. Hazards ratio (HR) and 95% confidence intervals (CIs) associated with height included in the model were age, weight, cigarette smoking habits, alcohol drinking habits, physical activity, economic status, age at menarche, and menopause status. After adjustment for all the covariates, each 5 cm increment in height was associated with 5% and 7% higher risk of overall cancer incidence in men and women, respectively. In case of site-specific cancers, a positive association was BMI (under vs. over 25 kg/m2), the effect of height on the risk of lung and prostate cancer incidence was predominantly observed among obese women only. These results suggest the association between height and cancer incidence might be modified by BMI status. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-391.