Abstract ID: 81 Monte Carlo simulations for boron neutron capture therapy to assessment absorbed dose of pancreas cancers

Abstract

Boron neutron capture therapy (BNCT) is a type of radio therapy, based on nuclear capture reaction that occurs when non-radioactive boron-10B is irradiated with neutrons with the appropriate energy to yield high energy alpha particles and recoiling lithium nuclei. Monte Carlo simulations by using MCNP5/X [1] code were applied for boron neutron capture therapy (BNCT) to estimate the dose for possible treatment of various cancers. The computational ORNL (Oak Ridge National Laboratory) phantom [2] was used to simulate tumour on the pancreas. Epithermal neutrons were considered in this simulation. As a product of neutron capture by 10B, alpha particle and 7Li are obtained. Since 7Li and 4He obtained after capture of neutron on 10B, have path lengths of approximately one cell diameter, their lethality is primarily limited to boron containing cells. The selective boron uptake in the pancreas metastases comparing to normal tissue makes BNCT a potentially advantageous technique, especially in treatment of whole organ. For the BNCT treatment planning it is important to determine the spatial distributions of absorbed dose which is determined by MCNP software in this work. Neutron beam parameters were defined by International Atomic Energy Agency (IAEA). The obtained theoretical results show that the BNC therapy may be used for the treatment of pancreas cancers.