Abstract
DNA is assumed to be the most critical target considering the biological effects of ionising radiation. Many radiobiological studies are lacking a detailed description of the irradiation set-up, which is particularly essential for experiments with heavy charged particles at the end of the Bragg peak when the LET varies considerably along the track. Using Geant4, several configurations of radiobiological experiments with liquid plasmid DNA have been simulated. The calculations revealed that even a slight variation in the setup can affect the distribution of dose and LET substantially, and therefore modify the yield of radiation damage. Ambiguous descriptions of the irradiation experiments led us to develop a Geant4-based application for biologists offering an easy way to model their radiobiology experiments, and provide them a tool to analyse the LET within their sample. It contains a library of widely used test tubes and selected other laboratory equipment to simplify the modelling for the user.
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