Abstract IA45: Genomics contributors to tumor subtypes in African American prostate and breast cancer patients

Abstract

Abstract African Americans suffer disproportionally in higher cancer incidence and worse overall survival in a number of cancer types. The reasons for the disparities are multifactorial and include differences in access to healthcare and lifestyle exposures, delayed disease diagnosis in socio-economically deprived communities, tumor biological differences, and factors related to genetics. Recent findings from multiple prostate and breast cancer genomics studies have identified subsets of ancestry associated genes that are associated with worse outcomes. Therefore, we will present an overview of these recent findings from our lab and others, specifically focusing on how these driver genes function a subset of tumors. Additionally, we will provide examples of how these ancestry-associated genes are integrated within regulatory networks, and discuss the possibility of ancestry specific subtypes promote aggressive disease in African American breast and prostate cancer patients. Citation Format: Clayton Yates. Genomics contributors to tumor subtypes in African American prostate and breast cancer patients [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr IA45.