Abstract
Abstract Tumors with mismatch repair deficiency are highly sensitive to checkpoint blockade. We will examine the mechanism of this sensitivity and also discuss mechanisms of treatment failure in tumors with this genotype. Citation Format: Luis A. Diaz. Tumor-intrinsic drivers of response and resistance to checkpoint blockade in MRD tumors [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2019 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(3 Suppl):Abstract nr IA25.
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