Abstract IA25: Systematic interrogation of KRAS function

Abstract

Abstract Oncogenic mutations of KRAS occur frequently in pancreas, lung and colon cancers. Recent efforts to target particular KRAS alleles or RAS effector pathways has led to clinical responses but resistance to therapy limits the effectiveness of these therapies. To understand the role of KRAS in tumor initiation and maintenance, we have used systematic approaches to understand dependencies in KRAS-driven cancers. Specifically, we have used genome scale gain and loss of function screens to interrogate pathways necessary for the survival of KRAS-driven cancers. We have identified genes that required for the survival of KRAS-driven cancers and that canonical RAS signaling proteins have multiple functions. Together these on-going approaches provide new insights into KRAS signaling and identify potential targets for combination therapies for KRAS driven cancers. Citation Format: William C. Hahn. Systematic interrogation of KRAS function [abstract]. In: Proceedings of the AACR Special Conference: Targeting RAS; 2023 Mar 5-8; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Res 2023;21(5_Suppl):Abstract nr IA25.