Abstract IA25: Detection of somatic mutations and HPV in saliva of patients with head and neck squamous cell carcinoma

Abstract

Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in the world and is associated with significant morbidity and mortality. HNSCC develops in the oral cavity, pharynx, and larynx and is associated with tobacco exposure, alcohol abuse, and infection with oncogenic viruses. Despite numerous diagnostic and therapeutic advances, HNSCC often presents with advanced disease and the long-term survival for patients with HPV-negative SCC has remained ~55%. Conventional analysis of tissue through cytopathology or histopathology is the mainstay of diagnosis. There are no useful biomarkers for disease diagnosis or surveillance. The genetic landscape of HNSCC has demonstrated that these tumors are largely driven by tumor-suppressor mutations. The broad mutation spectrum detected in HNSCC by these sequencing studies not only sheds light on its molecular pathogenesis, but also serves as a molecular signature that is exquisitely specific to the individual tumor. Therefore, methods that use these molecular signatures and biomarkers and aid in improved screening/early detection, prognostication, monitoring, and surveillance are paramount for improving outcomes. We will explore tumor DNA (somatic mutations and HPV DNA) in saliva and plasma for screening, monitoring, and surveillance and outline resulting implications for personalized medicine. In HNSCC, analysis of tumor DNA has the potential to enhance tumor profiling, aid in determining patient prognosis, and guide treatment decisions. Citation Format: Nishant Agrawal. Detection of somatic mutations and HPV in saliva of patients with head and neck squamous cell carcinoma [abstract]. In: Proceedings of the AACR Special Conference on Advances in Liquid Biopsies; Jan 13-16, 2020; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(11_Suppl):Abstract nr IA25.