Abstract IA13: Glioma stem cells and cancer

Abstract

Abstract Malignant GBMs are incurable tumors that progress within a year's time. Genome wide studies have pinpointed prevalent cancer associated mutions in GBM and among these, the tumor suppressors p53, Pten and NF1 are among the most frequently found. We have developed mouse models of GBM via mutation of p53, Pten and NF1 in the brain. Among the many key insights gleaned from studies with our mouse models have been: 1) The first demonstration that stem cells are the major source of these tumors. 2) The demonstration that all tumor cells are not equivalent and that the Cancer Stem Cells, a subpopulation of cells, are the root of tumor progression. 3) The discovery of a distinct form of GBM that arises in a different cell population and that has unique properties. This novel form of GBM has until now been grouped together with the predominant form of GBM. Our work will lead to a separation of prognosis and treatment for the different forms. In addition, using high throughput screens, we have small compounds in development that specifically target GBM cells but not normally dividing cells. I will discuss these advances and the implications for glioma, solid tumors and cancer in general. Citation Format: Luis F. Parada. Glioma stem cells and cancer. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr IA13.