Abstract IA12: Targeting the cell cycle in pediatric solid tumors

Abstract

Abstract My lab is interested in understanding how proliferation and differentiation are coordinated during development and how those processes become uncoupled in pediatric solid tumors. We are also interested in identifying tumor vulnerabilities that can be exploited therapeutically. We have developed a unique resource for studying the developmental origins of childhood solid tumors and this resource is shared freely with no obligation to collaborate through the Childhood Solid Tumor Network (www.stjude.org/cstn). We have also developed a rigorous and comprehensive preclinical phase I/II/III testing program (Langenau et al. Cancer Research, 2015) that recapitulate many of the features of human clinical trials. In my presentation, I will compare and contrast cell cycle and checkpoint vulnerabilities across 4 pediatric solid tumor types including ongoing efforts to exploit those vulnerabilities in preclinical studies and clinical trials. These examples will provide a foundation for targeting the cell cycle across diverse cancer types. Citation Format: Michael Dyer. Targeting the cell cycle in pediatric solid tumors. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(11_Suppl):Abstract nr IA12.