Abstract
Abstract The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous factors. The aspiration to utilize such ex vivo reprogrammed pluripotent and somatic cells for therapeutic purposes necessitates understanding of the mechanisms of reprogramming and elucidating the extent of equivalence of the in vitro derived cells to their in vivo counterparts. I will present and analyze our recent advances toward understanding these fundamental questions, and discuss the role of chromatin remodeling complexes in influencing the characteristics of pluripotency and reprogramming. I will further highlight future possibilities for utilizing epigenetic reprogramming for experimental and theoretical modeling of gene expression regulation, cell fate decisions and early mammalian development. Citation Format: Jacob H. Hanna. The epigenetic stability of pluripotent and somatic cell states. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr IA11.
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