Abstract
Abstract The Polycomb group (PcG) proteins have attracted a lot of attention, because of their documented role in regulating cellular identity and differentiation. Moreover, the expression of the proteins is frequently deregulated in human cancer, and the PcG proteins are therefore considered attractive targets for anti-cancer therapy. The PcGs generally form multi-subunit chromatin-modifying complexes to maintain transcriptional repression in multicellular organisms. However, the mechanisms leading to the recruitment of PcG proteins to target genes are still not completely understood. At the meeting, some of our recent findings understanding the mechanisms that regulate the binding of PcG proteins to target genes and how they contribute to transcriptional regulation will be presented. Citation Format: Xudong Wu, Eva M. Riising, Itys Comet, Kristian Helin. Mechanisms regulating polycomb group proteins to target genes. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr IA10.
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