Abstract
Abstract In an era of genomics-guided precision medicine, there is an increasing need for models that reflect the hallmarks of cancer and the molecular diversity of patient tumors. New cell culturing methods are transforming our ability to derive cell models from healthy and diseased tissues, with increased success rates, and linked to patient genomic and clinical data. I will update on our efforts as part of the Human Cancer Models Initiative (HCMI) to create a new biobank of molecularly annotated tumor organoids as a community resource. Furthermore, I will present how we are beginning to use these organoid cultures for chemical and genetic screens to identify new molecular targets and biomarkers of therapy response. These early studies are laying the foundation for a next-generation tumor organoid functional genomics platform to help guide the development of future precision cancer medicines. Citation Format: Mathew Garnett. Tumor organoid cultures as a platform for functional genomics [abstract]. In: Proceedings of the AACR Special Conference on the Evolving Landscape of Cancer Modeling; 2020 Mar 2-5; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2020;80(11 Suppl):Abstract nr IA09.
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