Abstract
Abstract The process of cell metastasis is characterized by a multistep process, the invasion-metastasis cascade. This involves cell invasion, intravasation into nearby blood vessels, passage into the circulation, followed by homing into predetermined distant tissues, the formation of new foci of micrometastases, and finally the growth of micrometastasis into macroscopic tumors. Multiple myeloma (MM) represents one of the best models to examine bone metastasis as it is characterized by the presence of multiple myelomatous “omas” throughout the skeleton, indicating that there is continuous trafficking of tumor cells to multiple areas in the bone marrow niches. We will examine intrinsic factors of clonal heterogeneity that mediate cell dissemination, as well as factors present in the bone marrow niche that are permissive for oncogenic proliferation. In addition, we will discuss advances that have been discovered in the complex process of invasion-metastasis in MM, and potential therapeutic agents that target the different steps of cell dissemination and progression. Citation Format: Irene Ghobrial. Multiple myeloma as a model of bone metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(17 Suppl):Abstract nr IA07.
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