Abstract
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic cancer and is predicted to be the second leading cause of cancer-related mortality in the next decade in Western countries. Treatment options are very limited, with even resectable tumours conferring a five-year survival rate of only 30%. Thus, there is an urgent need to better understand the biology of PDAC. Cancer cell heterogeneity is believed to be one of the main causes of tumour aggressiveness and resistance to therapy. I will describe our work to understand the sources of intratumoural PDAC diversity and the characterisation of a PDAC cancer stem cell population. Citation Format: Axel Behrens. Mechanisms of cellular heterogeneity in pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr IA-07.
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