Abstract
Abstract Multiple epidermal stem cell subpopulations in adult mouse skin have been identified over the last decade. Although they are all competent to give rise to all the different epidermal lineages following transplantation, wounding or genetic modification, under steady state conditions they maintain the epidermis in a compartmentalized manner. Stem cells in the lower hair follicle express LGR5, while stem cells in the upper follicle express LGR6 and cells in the junctional zone express LRIG1. In addition, a subset of stem cells in the interfollicular epidermis expresses LGR6. In my presentation I will discuss the consequences of selectively expressing activated beta-catenin in the different epidermal stem cell populations. Citation Format: Fiona M. Watt. Stem cells in mammalian epidermis. [abstract]. In: Proceedings of the AACR Special Conference: Developmental Biology and Cancer; Nov 30-Dec 3, 2015; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(4_Suppl):Abstract nr IA06.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
