Abstract
Abstract The majority of human solid tumors do not metastasize when grown subcutaneously in immunocompromised mice; this includes patient-derived xenograft (PDX) models. However, orthotopic implantation of intact tumor tissue can lead to primary tumor growth and metastasis that mimics that seen in patients. These patient-derived orthotopic xenograft (PDOX) models have a long history and better recapitulate human cancer than PDX models. Citation Format: Robert M. Hoffman. Patient-derived orthotopic xenografts (PDOX): Better mimic the patient than subcutaneous xenografts. [abstract]. In: Proceedings of the AACR Special Conference: Patient-Derived Cancer Models: Present and Future Applications from Basic Science to the Clinic; Feb 11-14, 2016; New Orleans, LA. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(16_Suppl):Abstract nr IA06.
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