Abstract IA023: Creating a single cell and spatial atlas of breast, ovarian and prostate cancer for African ancestry

Abstract

Abstract The US Black population is composed of both US born Black and immigrant Black populations from the Caribbean and Africa. Normal tissues in Black individuals independent of their country of birth or residence is woefully understudied. Black individuals disproportionately develop aggressive pathologic diseases which are treatment refractory or resistant, leading to premature deaths. In women, breast cancer is the most common cancer in Black women in the US, most common non-viral driven cancer in women in Africa and the Caribbean. Black women develop this disease younger than other ancestral groups and have higher incidence of metaplastic and triple negative breast cancer - aggressive pathologies. Ovarian cancer is rare in US-born Black (USB) while in both West and East Africa and the Caribbean, ovarian cancer is more common with more serous pathologies and earlier onset. While the incidence of prostate cancer among Black men in the US is declining, it is increasing in the Caribbean and Africa. Black men disproportionately develop prostate cancer young, have strong family history of prostate cancer, develop aggressive pathologies that are usually refractory to standard of care therapies. With the African-Caribbean Cancer Consortium (AC3) and Transatlantic Gynecologic Cancer Research Consortium, a single cell atlas of the cells of origin and tumors of breast, ovarian and prostate cancer will be constructed from samples across West and East Africa, the Caribbean and the USA in Black individuals. Pairing this single cell atlas with spatial approaches, we hope to develop a benchmark to confidently measure and interpret ancestral genomic differences at the cellular level. In this session, we will discuss how we are using these approaches to look at the relationship between African ancestry, aggressive disease biology, early onset warrants us to study the tissue composition, the proportion of sub-populations that are thought to give rise to tumors and the interplay with germline genetics. Citation Format: Jasmine Plummer. Creating a single cell and spatial atlas of breast, ovarian and prostate cancer for African ancestry [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA023.