Abstract
Abstract Human cancers have been classified for hundreds of years primarily by their anatomical location, and more recently by morphological criteria and the extent of local and distant spread. As cancer is quintessentially a genetic disease, genomics has allowed a reclassification of human cancers, including ovarian cancer, based on gene expression, epigenetic modification, mutational and copy number profiles. The presentation will describe how genomic analyses have helped highlight important molecular distinctions between and within histological subtypes of ovarian cancer, improved the diagnosis of rare subtypes, identified molecular subtypes with different biological properties and clinical outcomes, elucidated driver mutations in primary and recurrent disease, and suggested new approaches to the clinical management of ovarian cancer. Citation Format: David D. L. Bowtell. Genomic classification of ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr IA02.
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