Abstract
Abstract Comparative biology facilitates the exploration of the major factors that determine cancer susceptibility and resistance. We are only at the beginning of exploring the solutions that nature has found to the problem of preventing cancer, and the weaknesses that have evolved, leaving some animals exceptionally vulnerable to particular types of cancers. Some cancer defenses appear to be cell-intrinsic, such as the propensity of elephant cells to apoptose when they suffer DNA damage. Other defenses appear to depend on the environment, such as the invasion suppressive effects of fibroblasts of some species discovered by Wagner and his colleagues. I will review our early data on patterns of cancer prevalence across species and our initial results supporting Peto’s paradox but showing that contrary to our predictions, life history factors do not seem to explain patterns of cancer prevalence across species. Citation Format: Carlo Maley. Insights from comparative oncology [abstract]. In: Proceedings of the AACR Special Conference on the Evolutionary Dynamics in Carcinogenesis and Response to Therapy; 2022 Mar 14-17. Philadelphia (PA): AACR; Cancer Res 2022;82(10 Suppl):Abstract nr IA014.
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