Abstract
Abstract Many highly effective cancer drugs are available for the treatment of solid tumors but resistance almost invariably develops. The ability of cancers to acquire drug resistance by Darwinian evolution is widely accepted. Recently, cellular and microenvironmental plasticity were discovered as additional processes that can lead to drug resistance. I will discuss drug resistance evolution in colorectal cancer and show the need for a comprehensive framework that integrates Darwinian and non-Darwinian evolution in order to understand and address drug resistance evolution. Citation Format: Marco Gerlinger. Darwinian and non-Darwinian evolution of cancer drug resistance [abstract]. In: Proceedings of the AACR Special Conference on the Evolutionary Dynamics in Carcinogenesis and Response to Therapy; 2022 Mar 14-17. Philadelphia (PA): AACR; Cancer Res 2022;82(10 Suppl):Abstract nr IA003.
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