Abstract IA-09: Liver cancer and differences across Hispanic groups: Importance of disaggregation in understanding cancer disparities

Abstract

Abstract The incidence of hepatocellular carcinoma (HCC) has risen considerably in the US since 1980. The main causes include metabolic disorders (NAFLD, diabetes, obesity, metabolic syndrome), alcohol-related disease (ALD) and hepatitis C and B virus infections (HCV, HBV). Etiology-specific HCC incidence rates by detailed race-ethnicity are needed to improve HCC control and prevention efforts. All HCC cases diagnosed in Florida during 2005-2018 were linked to statewide hospital discharge data to determine etiology. Age-specific and age-adjusted rates were used to assess the intersection between etiology and detailed racial-ethnicities, including non-Hispanic White, non-Hispanic Black and Hispanic groups: Mexican, Cuban, Puerto Rican, Dominican, South, Central American. Of 19,956 HCC cases including 3,660 Hispanics, 87% matched with discharge data. For 2012-2018, HCV was the leading cause of HCC White, Black and Hispanic men (45.4%, 54.7% and 41.0% respectively) followed by NAFLD-related metabolic disorders and ALD. The leading cause of HCC among White and Black women was also HCV (38.3% and 50.2%) while for Hispanic women NAFLD-HCC (46.7%) was the most common form. Puerto Rican men had the highest HCV-HCC rates, 10.2 per 100 000. Metabolic-HCC rates were highest among populations above age 70 and among all Hispanics except Cubans. Mexican men had high rates of ALD-HCC. HCC etiology is associated with specific race/ethnicity. While HCV-related HCC rates are projected to decrease soon, HCC will continue to affect Hispanics disproportionately, based on higher rates of metabolic-HCC and ALD-HCC. Multifaceted approaches for HCC control and prevention are needed. Citation Format: Paulo S. Pinheiro. Liver cancer and differences across Hispanic groups: Importance of disaggregation in understanding cancer disparities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-09.