Abstract ES3-2: Optimizing Her2- directed treatment in early stage disease

Abstract

Abstract Amplification of HER2 is present in approximately 18-20% of all breast cancer, and targeted anti-HER2 therapies have transformed our approach for this subtype of disease. Trastuzumab-based chemotherapy remains the standard therapy for these patients, however, there remain several questions in determining the optimal treatment regimen: (1) What is the role of anthracyclines? ; (2) What is the optimal preoperative regimen?; (3) How do we treat small, node-negative HER2+ breast cancers?; (4) Should all patients receive pertuzumab, and in what setting?; (5)Does Trastuzumab-DM1 have a role in the early stage setting? This educational session will review the available data to address each of these questions, and will provide recommendations for optimizing HER2- directed therapy in the early stage setting. Citation Format: Tolaney S. Optimizing Her2- directed treatment in early stage disease [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr ES3-2.