Abstract EP09: Empiric Dietary Inflammatory Potential Is Associated With Elevated Left Ventricular Mass

Abstract

Background: Recent studies have shown associations between proinflammatory diets and several cardiovascular diseases. Whether a proinflammatory diet, assessed using the empirical dietary inflammatory potential (EDIP), is also associated with elevated left ventricular mass index (LVMI) in the general population is unknown. Methods: This analysis included 5,869 participants (55.9 ± 10.5 years; 48.5% male, 71.8% whites) from the Third National Health and Nutrition Examination Survey. EDIP score was calculated from the Food Frequency Questionnaire. LVMI was estimated using a validated electrocardiographic (ECG) model utilizing digitally recorded ECG data, which were processed automatically at a central core laboratory. Elevated left ventricular mass was defined as LVMI values ≥95th percentile (≥149 g/m2). Multivariable logistic regression was used to examine the association between EDIP score (tertiles and per 1-standard deviation (1-SD) increase, separately) and LVMI. Results: In multivariable logistic regression models, each 1-SD increase in EDIP score (0.259) was associated with 25% increased odds of elevated LVMI. Higher odds of elevated LVMI were observed with higher levels (tertiles) of EDIP suggesting a dose-response relationship (Table). These results were consistent in subgroups of the participants stratified by demographics and comorbidities. Conclusions: Dietary patterns with high proinflammatory properties are associated with an elevated LVMI. Given the association between cardiovascular mortality and an elevated LVMI, there needs to be a greater emphasis on the reduction of proinflammatory diet patterns.