Abstract
Abstract Metaplastic breast cancer (MPC) is a less common subtype of breast cancer, representing approximately 0.2-0.5% of breast cancer diagnoses, which is often associated with poor outcomes. MPC is an overarching term for breast tumors which demonstrate differentiation toward epithelial or mesenchymal components, or a mixture of these. In the context of challenging subtypes of breast cancer, thiseducational discussion will review epidemiology and clinical course of these tumors. Molecular characteristics of MPC and how this might impact current, as well as possible future, management strategies will be discussed. Finally, opportunities for laboratory investigations and clinical trial approaches to further understand and better treat MPC will also be discussed. Citation Format: Alexandra Thomas. Metaplastic Breast Cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr ED4-2.
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