Abstract
Abstract Numerous high-profile publications have confirmed that an individual tumor contains hundreds of mutations, that a tumor will continue to acquire mutations as it progresses, and that significant tumor heterogeneity exists not only between tumors but also within a tumor. Because of these challenges, prevention of cancer should be more effective than treating end-stage disease. Mouse models are useful tools for developing new drugs and strategies for cancer prevention, and we have used mouse models of breast, pancreas, and lung cancer to ask different types of questions. Our data demonstrate the benefits of early intervention in the process of carcinogenesis. Moreover, multifunctional drugs that target key regulatory nodes are more effective than targeted therapies for prevention, and combining drugs that target different pathways or cell types can enhance the potency and reduce the toxicity of individual drugs. Citation Format: Karen T. Liby. Using mouse models to develop new drugs and strategies for prevention. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr ED02-04.
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