Abstract D125: Disparities in cervical cancer mortality across the Siberian related ethnic regions: The Republic of Sakha, the Republic of Khakassia, Buryatia, the Altai Republic, and Tuva (2007-2017)

Abstract

Abstract Introduction. Cervical cancer mortality (CCM) varies throughout Russia, including Siberia. Nevertheless, disparities in CCM of Siberian native ethnic population have not yet been investigated. The objective of this study was to determine the differences of CCM during 2007-2017 in Siberian regions, where gene related ethnic groups live – the Republic of Sakha (Sakha), Buryatia, the Republic of Khakassia (Khakassia), the Altai Republic (Altai) and Tuva. Four out of these five regions, except for Sakha, geographically located in the south of Siberia. Sakha is located in the northern part of Siberia. Methods. Annual mortality rates from cervical cancer were analyzed from 2007 to 2017. This data was obtained from the annual reports entitled “Malignant neoplasms in Russia (incidence and mortality)” of P. Hertzen Moscow Oncology Research Institute - branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation. Age-adjusted mortality rates (per 100,000 populations) were compared for each region - Sakha, Buryatia, Khakassia, Altai and Tuva. Kruskal-Wallis H-test was used to determine the statistically significant differences in CCM variances of three or more regions and Mann-Whitney U test for two regions. T-test was used to determine the statistically significant differences in paired CCM rates. Differences with a probability less than the significance level of 0.05 were considered as a statistically significant. Results. Comparisons showed CCM heterogeneity between all five regions of Siberia. The highest CCM rates from 2007 to 2017 were found in Buryatia - the average value of CCM rates (avCCM) is 11.46. CCM rates in this region from 2007 to 2017 were significantly higher than in all other regions, except for the Tuva. The lowest mortality rates during the observed timeframe were detected in Sakha, avCCM - 5.82. Mortality rates in Sakha during this timeframe were significantly lower compared to the other four regions. CCM rates comparison of Altai (avCCM - 9.85), Tuva (avCCM - 9.62) and Khakassia (avCCM - 7.76) did not reveal the significance of the differences between these three regions (although was close to significance). But when paired comparison of CCM variances was used, the CCM rates in Tuva were significantly higher than in Khakassia. When all regions’ CCM rates in 2007 to 2017 were compared, then no significant changes of four regions, except for Altai, were found. In the Altai, compared to 2007, the mortality rate in 2017 significantly decreased, about 2 times (7.61 vs. 15.97). Conclusion. Despite the genetic relationships of the native ethnic populations of Siberia, CCM in the analyzed regions between 2007 and 2017 differs. The highest CCM were observed in Buryatia. The lowest mortality rates were detected in Sakha. CCM rates for the Altai, Tuva and Khakassia were not significantly different. CCM in the Altai in 2007 compared to 2017 decreased twice. The same comparison in Sakha, Khakassia, Buryatia and Tuva showed no changes. Citation Format: Irina V. Kononova, Sargylana N. Mamaeva, Maria P. Kirillina, Petr V. Nikiforov. Disparities in cervical cancer mortality across the Siberian related ethnic regions: The Republic of Sakha, the Republic of Khakassia, Buryatia, the Altai Republic, and Tuva (2007-2017) [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr D125.