Abstract CT130: Intravenous chemotherapy plus intraperitoneal perfusion chemotherapy for gastric cancer: A systematic review and meta-analysis

Abstract

Abstract Purpose: This a review of randomized controlled trials (RCTs) of intravenous (IV) with or without intraperitoneal (IP) chemotherapy in patients with gastric cancer to determine the impact on effect and safety. Methods: Databases, including Medline, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, Current Controlled Trials, and CINAHL were electronically searched for RCTs up to June 2013, and relevant references of the included articles were also manually searched. Two authors independently searched articles, extracted data, and assessed the quality of included studies. Meta-analyses were performed on the included data, for the outcomes survival rate, metastasis rate and adverse events. The Grading of Recommendations Assessment, Development and Evaluation System was used to rate the level of evidence. Results: Five RCTs involving 1072 patients were included. Overall, a significant improvement in overall survival rate [relative risk (RR) = 1.21, 95% confidence interval (95% CI) 1.13 to 1.29, P<0.01], one-year survival rate (RR = 1.10, 95% CI 1.04 to1.17, P = 0.005), three-year survival rate (RR = 1.22, 95% CI 1.11 to1.35, P = 0.001), and five-year survival rate (RR = 1.42, 95% CI 1.12 to 1.80, P = 0.004) were associated with IV plus IP chemotherapy. Meta-analysis demonstrated that metastasis rate can be effectively decreased (RR = 0.35, 95% CI 0.25 to 0.50, P<0.01) but incidence of adverse events were increased using IV plus IP chemotherapy. Conclusion: IV plus IP chemotherapy in patients with gastric cancer is associated with improved overall survival and prevented distant or peritoneal metastasis. However, increased risk of neutropenia, peripheral edema and neuropathy are also demonstrated. Citation Format: Sheng Yang, Rui Feng, Zhangchi Pan, Tao Jiang, Qian Xu, Qiang Chen. Intravenous chemotherapy plus intraperitoneal perfusion chemotherapy for gastric cancer: A systematic review and meta-analysis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr CT130. doi:10.1158/1538-7445.AM2015-CT130