Abstract C36: Gastric intestinal metaplasia: Epidemiological and demographic characterization in Puerto Rican Hispanics

Abstract

Abstract Background: Gastric intestinal metaplasia (GIM), a key event in gastric carcinogenesis, is the replacement of gastric mucosa by an epithelium that histologically resembles intestinal mucosa. Helicobacter pylori (H. pylori), the most common chronic bacterial infection in humans, is known to be associated with gastric carcinogenesis. Classification of GIM by histological subtype and pattern sets an important goal for proper surveillance measures. Incomplete GIM confers 4- to 11-fold increased risk for gastric cancer. Despite this, there is no previous data available of GIM prevalence and characterization in Puerto Rico (PR). The aim of this study is to determine the prevalence of GIM within the cohort of patients in PR who underwent diagnostic endoscopy for the period of 2012-2014, and to characterize the demographical and clinicopathological profile of individuals with GIM. Methods: A cross sectional study design using pathology reports of 4,707 endoscopic biopsies with confirmed diagnosis of GIM between 2012-2014 was performed. These reports were reviewed, and the demographic, geographic, and histopathological data provided were analyzed for characterization of this condition. Study characteristics were described using frequency distributions for categorical variables. SPSS version 17 was used for statistical analysis. Results: Between 2012-2014, the prevalence of GIM was 10.7%, of which 26.9% of cases were positive for H. pylori. GIM was frequently found at incisura angularis and antrum biopsies. Approximately 99.6% and 71.2% of the reviewed pathology reports lack information about GIM histological subtype and pattern. Conclusion: The prevalence of GIM is difficult to establish due to asymptomatic nature of the lesion, insufficient number of biopsies or inappropriate localization of biopsies. Despite this, the prevalence of GIM in PR appears to be higher than in United States. We observed that pathology reports lack the proper characterization of GIM necessary to provide adequate surveillance. Citation Format: Maria Gonzalez-Pons, Jorge J. Cruz-Cruz, Cepero Carla, Alberto Del Valle, Giancarlo Colon, Kimberly Alicea, Kathia Rosado, Marcia Cruz-Correa. Gastric intestinal metaplasia: Epidemiological and demographic characterization in Puerto Rican Hispanics. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr C36.