Abstract C075: Increasing incidence of cutaneous malignant melanoma in the Hispanic population of the United States from 2006-2017

Abstract

Abstract Melanoma is the fifth most commonly diagnosed cancer in the United States (US), and its incidence has been rapidly increasing within the past several decades. Previous studies have shown that individuals with darker skin tones are less likely to survive melanoma than those with lighter skin tones. Despite this increased morbidity in skin of color populations, limited studies have investigated how melanoma affects different races and ethnicities. Herein, we conducted a population-based registry study to assess the incidence and survival pattern of cutaneous malignant melanoma (CMM) subtypes in the US from 2006 to 2017. In addition, we examined the four major histological CMM subtypes (superficial spreading, lentigo maligna, nodular, and acral lentiginous melanoma) and its distribution by race, gender, and tumor grade. Data from 17 population-based cancer registries from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed, and 58,666 histologically confirmed cases of CMM were evaluated. Acral lentiginous melanoma was diagnosed predominantly in non-Hispanic whites (56%) and Hispanic whites (45%). Melanomas that were not of the four major histological CMM subtypes were predominant in the Asian (54%) and Black (77%) populations. Superficial spreading and lentigo maligna melanomas presented more commonly in males (69% and 63%, respectively). Nodular and lentigo maligna melanomas had the poorest survival rates (median of 26 and 21 months, respectively). The incidence rate of CMM has been steadily increasing in the Hispanic population, with Hispanic whites having the highest incidence of acral lentiginous melanoma when compared to other skin of color populations. Thus, it is important we continue to assess and trend the epidemiological characteristics of CMM subtypes. In addition, future studies should investigate the possible genetic and environmental factors that may be contributing to the increased incidence of CMM in skin of color populations and its associated morbidity. Citation Format: Yae L. Kye, Cicilyn Xie, Hannah Riva, Michelle Samaniego, Fabiola Ramirez, Lorena Fernandez, Luis Alvarado, Alok Dwivedi, Jessica Chacon. Increasing incidence of cutaneous malignant melanoma in the Hispanic population of the United States from 2006-2017 [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C075.