Abstract C018: Prognostic worth of Nrf2/BACH1/HO-1 signals in the development of breast cancer

Abstract

Abstract Nrf2/BACH1/HO-1 signals have been implicated in the development and progression of tumors. However, there has been no comprehensive analysis of their expressions in breast cancer. This study evaluated Nrf2/BACH1/HO-1 signals expression and its clinical significance in breast cancer. 114 female breast cancer of different pathologic parameters and non-cancerous tissues were evaluated for Nrf2/BACH1/HO-1 signals expression using immunohistochemistry and western blot. The relationship connecting Nrf2/BACH1/HO-1 expression and clinicopathologic factors were assessed using the chi-square test. Nrf2 protein in cancerous tissues (74%) was significantly higher than in the non-cancerous tissues (43% p < 0.002), BACH1 expression in cancerous tissues (61%) was significantly lower than that of non-cancerous tissues (20% p < 0.031) and HO-1 protein expression in cancerous tissues (67%) was highly significant than in the non-cancerous tissues (17% p < 0.001). The expressions of Nrf2 and HO-1 significantly correlated with tumor grade whilst BACH1 was significantly associated with tumor stage (p < 0.05). Nrf2, BACH1 and HO-1 play key roles in the growth and development of breast cancer and can serve as probable biological markers for breast cancer diagnosis, prognosis as well as therapeutic targets. Citation Format: Precious Barnes, Roland Osei Saahene. Prognostic worth of Nrf2/BACH1/HO-1 signals in the development of breast cancer [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr C018.