Abstract B91: Self-reported prior lung disease as risk factors for non-small cell lung cancer in Mexican Americans

Abstract

Abstract Background: Although cigarette smoking is the primary risk factor for lung cancer, other risk factors have been shown to be associated with lung cancer including prior history of respiratory diseases. The purpose of this analysis was to assess the association between prior history of respiratory disease (i.e., asthma, chronic obstructive pulmonary disease (COPD), hay fever, and pneumonia) and lung cancer among Mexican Americans using data from a multi-racial/ethnic lung cancer case-control study. Methods: The data were collected between 1991 and 2010. Cases (n = 217) were patients who presented with newly diagnosed, histopathologically confirmed and previously untreated lung cancer. Healthy control participants (n = 339) were recruited from a large multispecialty physician group practice. Demographics, cigarette use, and history of respiratory disease were collected by personal interview using a validated questionnaire. Multivariable logistic regression models were used to estimate relative risk. All analyses were restricted to self-report Mexican Americans. Results: Prior history of COPD (OR = 2.33; 95% CI = 1.14–4.79) and pneumonia (OR = 2.88; 95% CI = 1.47–5.63) were associated with a statistically significant increased risk of lung cancer. Conversely, self-reported history of asthma (OR = 0.71, 95% CI = 0.20–2.45) or hay fever (OR = 0.59, 95% CI = 0.29–1.21) were inversely associated with lung cancer risk but the odds ratios were not statistically significant. Conclusions: These findings illustrate that COPD and pneumonia are associated with an increased for lung cancer among Mexican Americans. Identifying risk factors such as C. pneumonia infections and COPD may induce targeted treatments to help attenuate progression to lung cancer. At present this study is one of largest case-control analyses assessing respiratory disease and lung cancer risk among Mexican-Americans. Citation Information: Cancer Prev Res 2011;4(10 Suppl):B91.