Abstract B82: Metabolic risk factors and colorectal adenoma risk in Korean population

Abstract

Abstract Recent epidemiologic studies reported that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the exact mechanism is not clearly explained, it might be mediated by several process including insulin resistance, dysregulation of insulin-like growth factor axis, oxidative stress, DNA damage, and adipokine production. The objective of the current study was to assess the associations between metabolic risk factors and the risk for developing colorectal adenomatous polyp according to detailed clinical information on polyps in a large colonoscopy-based study. The study participants visited the National Cancer Center, Korea for cancer screening between April 2007 and April 2009. A total of 1,771 newly diagnosed colorectal adenoma patients and 4,967 polyp-free controls were included in the analysis. Metabolic syndrome was defined based on the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria with a modified waist circumference for Asian population. In men, high body mass index, waist circumference, blood pressure, and triglyceride were associated with an increased risk for colorectal adenoma. Possessing three and more metabolic risk factors was associated with an increased risk for adenoma (OR = 1.49, 95% CI = 1.23-1.81). The association between metabolic syndrome and colorectal adenoma was observed for the risk for right colon adenoma (OR = 1.64, 95% CI 1.27-2.10) or adenomas in multiple anatomical locations (OR = 1.55, 95% CI = 1.12-2.15). In women, high waist circumference and triglyceride were associated with an increased risk for adenoma, and metabolic syndrome was associated with a high risk for adenoma (OR = 1.45, 95% CI 1.09-1.94), especially that for adenoma of left colon (OR = 1.62, 95% CI = 1.02-2.59). In conclusion, metabolic risk factors and metabolic syndrome were risk factors for colorectal adenoma, and the increased risks were more prominent for right colon adenoma in men and left colon adenoma in women. Citation Information: Cancer Prev Res 2010;3(12 Suppl):B82.