Abstract B59: The effect of resveratrol on azoxymethane (AOM)-induced colon carcinogenesis in mice with aberrant crypt foci (ACF)

Abstract

Abstract Introduction: Resveratrol (trans-3,4,5-trihydroxy-trans-stilbene) is a naturally occurring phytoalexin with antioxidant and antiinflammatory properties. Moreover, recent studies suggest that resveratrol possesses anticancer effects on the major stages (initiation, promotion and progression) of malignant transformation. The present study was designed to investigate the effect of resveratrol on azoxymethane (AOM)-induced colon carcinogenesis in mice with aberrant crypt foci (ACF). Methods and Results: 8-week-old male C57/BL6 mice were randomly assorted into experimental five groups and administered several doses resveratrol (0.1, 1, 10, 50mg/kg/day). All mice were injected twice (1 week apart) of 10 mg/kg AOM, and sacrificed 6weeks after the first injection of AOM. Colon and rectum were stained with methylene blue for the determination of ACF. The number of ACF was significantly decreased in groups of mice treated with resveratrol in dose-dependent manner. Discussion: Colorectal cancer (CRC) poses a major clinical challenge in the developed world where the disease is common. However chemoprevention is defined as the use of natural, synthetic or chemical agents to reverse, suppress or prevent carcinogenic progress. No drug is confirmed for CRC chemoprevention. Present study demonstrated resveratrol may have chemopreventive effect for CRC. Resveratrol considered to be a food supplement and a relatively safe natural medication, so seems to be tolerated to long-term administration for CRC chemoprevention. Citation Information: Cancer Prev Res 2010;3(12 Suppl):B59.