Abstract B53: Time to first cigarette and lung cancer risk in Japan

Abstract

Abstract Background: Cigarette smoking is the major cause of lung cancer. Although the time to first cigarette (TTFC) of the day is a distinct indicator of nicotine dependence, little information is available on its possible relation to LC. Methods: This case-control study includes a total of 1,572 incident lung cancer cases and 1,572 non-cancer controls visiting for the first time the Aichi Cancer Center Hospital between 2001 and 2005. We estimated odds ratio (OR) and 95% confidence interval (CI) for TTFC using logistic regression model after adjustment for several potential confounders. Results: TTFC was inversely associated with the risk of lung cancer. This association was consistent across histological subtypes of lung cancer. For all lung cancers considered among ever smokers and after accurate allowance for smoking quantity and duration, besides other relevant covariates, compared with TTFC more than 60 min, the adjusted ORs were 1.08 (95% CI, 0.73-1.61) for TTFC of 31-60 min, 1.40 (0.98-2.01) for 6-30 min and 1.86 (1.28-2.71) for within 5 min (ptrend, <0.001). Statistically significant heterogeneity by histological subtype was observed (pheterogeneity, 0.002 for former smokers and 0.033 for current smokers). Conclusions: Nicotine dependence, as indicated by the TTFC, is associated with increased risk of lung cancer and is therefore an independent marker of exposure to tobacco smoking. Citation Format: Hidemi Ito, Silvano Gallus, Satoyo Hosono, Isao Oze, Koichi Fukumoto, Yasushi Yatabe, Toyoaki Hida, Tetsuya Mitsudomi, Eva Negri, Calro La Vecchia, Hideo Tanaka, Keitaro Matsuo. Time to first cigarette and lung cancer risk in Japan. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B53.