Abstract B5: Personal and social predictors of sharing genetic test results within the family

Abstract

Abstract Purpose: As testing for cancer susceptibility gene mutations becomes more prevalent, there is a growing need to understand the challenges faced by probands as they attempt to share genetic test results with family members. This study reports on a communication skills intervention, guided by the Theory of Planned Behavior (TPB), to improve the process of communication. Methods: Participants seeking BRCA1/2 genetic testing were randomized to a communication skills-building intervention or a wellness control. Primary outcome was the number of first degree adult relatives with whom results were shared and ease of sharing. Questionnaires addressed TPB tenets and psychosocial factors. Results: 233 participants shared test results with 743 of their 907 eligible relatives (81.9%). There was no significant difference between intervention and control in sharing test results, or in the level of sharing-related distress. When data from both arms were combined, the proband's perception of her relative's opinion about genetic testing and her confidence in effectively sharing results were strong predictors of sharing. Results were more likely to be shared with female relatives and with children. Conclusion: While this data does not support a communication intervention in improving the sharing of genetic test results, it does identify the importance of the proband's perception of her relative's opinion of genetic testing and her perceived ability to relay this information. It highlights the selective nature of sharing, with male relatives and parents less likely to be recipients. Impact: Psychosocial factors play a significant role in the communication of genetic test results within families. Citation Information: Cancer Prev Res 2010;3(12 Suppl):B5.