Abstract
Abstract Helicobacter pylori infection has been implicated in acute gastritis, chronic atrophic gastritis, peptic ulcers as well as gastric cancer. Since we have documented that anti-H. pylori, anti-inflammatory, anti-oxidative, and anti-mutagenic actions of Korean red ginseng and the enhancing anti-inflammatory activities and attenuating anti-inflammatory roles of Lactobacillus plantarum, in the current study, we investigated the effects of L. plantarum-fermented Korean red ginseng on subacute or chronic pathology in H. pylori-infected mouse model. 5-week-old interleukin-10 deficient mice were inoculated with H. pylori (Sidney strain 1), after which L. plantarum (Lp), Korean red ginseng (RG) and fermented Korean red ginseng (FRG) were administrated by drinking water for 14 or 24 weeks. After killing, in addition to gross and pathologic evaluations, the expressions of inflammatory enzymes or cytokines were analyzed by Western blot analysis or ELISA, respectively. H. pylori infection induced the expression of inflammatory enzymes, iNOS and COX-2, and cytokines such as IL-1β and IL-6 in subacute 14 weeks model. Moreover, H. pylori infection significantly provoked tumorigenesis in chronic 24 weeks model. Lp, RG and FRG inhibited the expression of inflammatory enzymes and cytokines in both subacute and chronic models. Among those, FRG showed the significant anti-inflammatory and anti-tumorigenic effects on H. pylori-infected gastric carcinogenesis reflected with decreased incidence of tumor formations. Probiotics fermented Korean red ginseng exerted significant protections against H. pylori infection through attenuating gastritis, rescuing from tumorigenesis and enhancing gastroprotection. We suppose that chronic intake of FRG can be an anticipating strategy in chemoprevention of H. pylori-associated gastric cancer. Citation Information: Cancer Prev Res 2011;4(10 Suppl):B45.
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