Abstract
Abstract Oral squamous cell carcinoma (OSCC) is the most frequent cancer and constitutes a major health problem in India, representing the leading cause of death. The aim of the present investigation was to study the major chromosomal aberrations (CA) like deletion, translocation, inversion and mosaic in OSCC patients of South India. Genetic factors play an important role in the etiology of OSCC. Totally 300 oral sumucosa fibrosis symptoms patients were chosen from various hospitals from southern india by advent screening like Toluidine blue staining and brush biopsy. Finally 103 severely affected OSCC patients were selected. 5ml of peripheral blood samples were taken from affected patients. Equal numbers of normal healthy control subjects were chosen after signing a consent form. Cytogenetic studies were performed by using Giemsa-banding technique and finally the results were ensured by spectral karyotyping (SKY) technique. In the present investigation, major CA like deletion, translocation, inversion and mosaic were identified in experimental subjects. Results showed frequent CA in chromosomes 3p, 3q, 8p, 7p, 9p, 11q, 17p, 19q and X. In comparison with experimental subjects, the control subjects exhibited very low levels of major CA (P<0.05). In the present study, the high frequency of centromeric rearrangements indicates a potential role for mitotic irregularities associated with the centromere in OSCC tumorigenesis, interesting chromosomal regions which may harbor susceptibility genes. Identification of chromosome alterations may be helpful in understanding the molecular basis of the disease in a better manner. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B45.
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