Abstract B37: Prognostic analysis of primary hepatic carcinoma with cancer embolus of biliary duct

Abstract

Abstract Background: In China, primary hepatic carcinoma (PHC) is one of the most frequent malignancies, which is more accompanied by cancer embolus of portal vein and is less with cancer embolus of biliary duct (CEBD) clinically. Anterior cases were diagnosed as PHC with CEBD by B ultrasound, CT, MRCP, or ERCP. Hepatectomy and choledochotomy were performed resecting the primary tumor and cleaning the CEBD completely, followed with TACE after operation. Nowaday ultrasound in biliary duct and orthotopic liver transplantation were worth considering as a brand new and extreme diagnose and treat method respectively. The article was intended to evaluate the clinicopathological characteristics and the prognosis of PHC with CEBD by therapeutic effect contrast to PHC with CEBD in different location. Methods: The clinical data of 412 PHC patients with CEBD underwent surgical hepatectomy from 2000 to 2009 in the several hepatobiliary surgery centers of hospitals in China were retrospectively analyzed to research the clinicopathological characteristics and the prognosis. All the patients were divided into three groups based on distribution and location of CEBD. Results: The overall 1 -year, 3-year, and 5-year survival rates from the time of operation were 76.8%, 53.4%, and 40.1 %, respectively. There was no significant difference in the prognosis between PHC patients with or without CEBD (P>0.05). Independent factors affecting the prognosis of PHC patients were infiltration growth and multiple development. CEBD had no contribution in the prognosis of PHC patients. But the prognosis was different in PHC patients with different locations of cancer embolus in the biliary duct (P<0.05). Conclusion: Surgical operation remains the most effective treatment to PHC patients with CEBD. CEBD had no contribution in the prognosis of PHC patients. The location of the cancer embolus in the biliary duct was significant factors affecting the prognosis of PHC patients with CEBD. The prognosis was the worst in those PHC patients with CEBD located in the right hepatic duct. Citation Information: Clin Cancer Res 2010;16(14 Suppl):B37.